Orlistat tablet.
TrustScore 4.9/5107 reviewsOrlistat — the longest-established weight-loss medicine — works in your gut, not your brain, blocking around a third of the fat you eat. A needle-free capsule, prescribed where clinically appropriate by a UK prescriber.
Orlistat with PPRX — the private prescription, clinical review and free next-day delivery are all part of one price.
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for the 120 mg × 84 capsules dose · per pack · about four weeks
You save £10 on every order
Includes prescription, clinical review & delivery · Subject to clinical consultation
Orlistat is a lipase inhibitor — the same medicine as branded Xenical. Rather than changing your appetite, it works entirely in the digestive system: it blocks the enzymes that break down dietary fat, so around a third of the fat you eat passes through unabsorbed instead of being stored.
It's the affordable, needle-free option — a capsule taken with each main meal, no titration and no fridge. Average weight loss is more modest than with the injectable treatments, but it has decades of real-world use and works best alongside a reduced-calorie, lower-fat diet.
Active ingredient
Orlistat
Class
Lipase inhibitor
Cadence
With main meals
Dose range
120 mg
Form
Oral capsule
From
£34.99 / mo
How Orlistat works.
Orlistat works in your gut, not your brain — it stops part of the fat in your food from ever being absorbed.
orlistat
up to 3× daily tablet
Blocks the digestive enzymes that break down dietary fat, so around a third passes through unabsorbed.
Because unabsorbed fat means unabsorbed calories, every meal effectively gets lighter — without acting on appetite hormones. It's a fundamentally different approach from the GLP-1s, and the reason a lower-fat diet matters so much while taking it.
Honest about side effects.
Most side effects are caused by the fat orlistat blocks leaving the body — keeping each meal below roughly 15 g of fat prevents most of them. A bedtime multivitamin covers vitamins A, D, E and K, and your pharmacist is a message away if anything feels off.
Common & usually mild
- Oily or fatty stools
- Needing the toilet urgently
- Wind, with or without oily spotting
- Stomach pain
- Loose stools
Rare & serious
Rare but serious effects include pancreatitis and rectal bleeding. Seek urgent care for severe, persistent abdominal pain or blood in your stools.
Always read the patient information leaflet. This page is information, not a substitute for the clinical advice you'll receive in your consultation.
The longest-established licensed weight-loss medicine.
Numbers come from the registration trial, not marketing averages — and only ever happen alongside diet, activity and clinical follow-up.
~10%
average body-weight reduction
52 wks
trial duration
24–48 h
until fat-blocking begins
One-year randomised trial, orlistat 120 mg three times daily vs placebo, alongside a reduced-calorie diet. Results vary and are more modest on average than with GLP-1 treatments.
What Orlistat could mean for you.
Set the slider to where you are today and watch the trial average become actual kilograms — with medication and support, versus the same trial's group who had lifestyle changes alone.
An illustration, not a promise — your prescriber sets real expectations.
98kg
on the trial average, −10.0 kg
One dose, from day one.
There's no ramp-up with Orlistat — the dose is the same from your first day to your last. What matters is the routine around your meals, and the review that checks it's working for you.
Every day
1 × 120 mg with each main meal
Up to three capsules a day — before, during, or within an hour of eating
Missed a meal?
Skip that capsule
No fat in the meal means nothing for orlistat to block
Alongside
A daily multivitamin
Taken at bedtime, to cover fat-soluble vitamins A, D, E and K
Week 12 review
Progress check
Your clinician reviews whether treatment is working for you
The full price list, up front.
No dose ladder here — one flat price for each option. Each price is per pack (about four weeks of daily tablets) and includes the prescription, clinical review and delivery.
| Dose | Price per pack |
|---|---|
| 120 mg × 84 capsules | £34.99 |
All sales are subject to prescriber approval following a free online consultation.
Prescribed, dispensed, delivered.
One all-in price per pack— the medication, the private prescription, clinical review and free next-day delivery. The consultation is free, and a subscription is optional — Subscribe & Save for £10 off every order, or order one-off.
- Reviewed by a UK-registered prescriber
- Discreet, next day — no needles, no fridge
- Subscribe & Save or order one-off — no lock-in
Subject to clinical consultation
Everything, for one price.
Your Orlistat price is all-in — the medicine and the care around it, with nothing bolted on afterwards.
Check my eligibility
The genuine medication
Genuine, UK-licensed medicine dispensed by our GPhC-registered UK pharmacy.
Private prescription included
A UK-registered prescriber reviews your consultation before anything is dispensed — the prescription is part of the price.
Clinical review
Every order is checked by our pharmacy team, with ongoing support as your dose changes.
Free next-day delivery
Tracked, discreet packaging, delivered free the next day — no fridge required.
Pharmacist support
Message our pharmacy team whenever you have a question about your treatment.
Your choice of plan
Subscribe & Save for £10 off every order, or order one-off. Pause or cancel anytime.
Orlistat
questions.
The questions we hear most about Orlistat. Anything else, write to info@pprx.co.uk.
How much weight can I expect to lose on orlistat?
How do I take orlistat?
What's the difference between orlistat, Xenical and Alli?
How does orlistat compare to Mounjaro or Wegovy?
Do I need to change how I eat?
Is orlistat available on the NHS?
From the journal.
Essays from the clinicians who write your prescriptions — explainers, second-look reviews, and the occasional plain-English correction.
Wegovy Tablets vs Wegovy Injections: Which Weight Loss Option Is Right for You?
Wegovy Tablets vs Wegovy Injections: Which Weight Loss Option Is Right for You?
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Medically reviewedThis Orlistat page is reviewed by Omar Kadir, Superintendent Pharmacist, MPharm (GPhC 2078291). For full prescribing and safety information, see the patient information leaflet supplied with your medicine or the electronic medicines compendium.
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free consultation.
Three minutes of your time, reviewed by a UK-registered prescriber. No commitment, no charge for the consultation — and if treatment is approved, free next-day delivery to your door.