Foundayo tablet.
TrustScore 4.9/5119 reviewsOrforglipron — a GLP-1 medicine in a once-daily tablet you can take at any time of day, with or without food. No needles, no fridge, no waiting to eat. Coming soon to PPRX.
Coming soon
Prescription-onlyFoundayo isn't available from PPRX just yet. Join the waitlist and we'll email you as soon as it is.
- Approved in the US (FDA)April 2026
- Approved in the UK (MHRA)August 2026
- Available from PPRXComing soon
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Foundayo is orforglipron, a GLP-1 receptor agonist made as a small-molecule tablet rather than an injected peptide. It's a prescription medicine for adults with obesity, or with overweight and a weight-related health problem, used alongside a reduced-calorie diet and more physical activity to lose weight and keep it off.
What sets it apart from other GLP-1 tablets is the routine: one tablet a day, whenever suits you, with or without food and with no restrictions on water. Like the injectable GLP-1s, it starts at a low dose and steps up gradually so your body has time to adjust.
Active ingredient
Orforglipron
Class
GLP-1 agonist
Cadence
Once daily
Dose range
0.8–17.2 mg
Form
Oral tablet
At PPRX
Coming soon
Benefits that go further than weight.
Orforglipron is a GLP-1 tablet with no food or water rules — and in trials its benefits reached past the scale, to the heart-health markers your clinician watches.
Take it any time of day
One tablet a day, with or without food, and no rules about water.
Improves heart-health markers
In trials, blood pressure, triglycerides and cholesterol improved alongside weight loss.2
A small molecule, not a peptide
Orforglipron survives digestion on its own, so it doesn't need an empty stomach to work.
1Helps reduce the risk of major cardiovascular events, such as heart attack and stroke.
2As part of a balanced diet and healthy lifestyle.
How Foundayo works.
Orforglipron switches on the same GLP-1 receptor as semaglutide — but it's a small molecule, not a peptide, so it survives digestion without special handling.
orforglipron
once daily tablet
Curbs appetite, slows stomach emptying, and tells the brain you're full for longer.
Because the tablet doesn't need an empty stomach to be absorbed, there's no morning ritual to plan around — one tablet, any time of day, with or without food or drink.
Honest about side effects.
Nausea, vomiting and diarrhoea are most likely when you start or step up a dose, and generally ease with time. Smaller meals, blander food, less fat and plenty of fluids all help — and each dose is held for at least 30 days before moving up.
Common & usually mild
- Nausea
- Constipation
- Diarrhoea
- Vomiting
- Indigestion
- Stomach pain
- Headache
Rare & serious
Stomach problems can sometimes be severe, and fluid loss from vomiting or diarrhoea can lead to dehydration and kidney problems. Foundayo must not be taken by anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, and should not be combined with another GLP-1 medicine.
Always read the patient information leaflet. This page is information, not a substitute for the clinical advice you'll receive in your consultation.
A daily tablet, tested over 72 weeks.
Numbers come from the registration trial, not marketing averages — and only ever happen alongside diet, activity and clinical follow-up.
11.1%
average body-weight reduction at the 17.2 mg dose
72 wks
trial duration
2.1%
average reduction with placebo in the same trial
72-week study of orforglipron vs placebo in adults without diabetes; average loss was 7.4% at 5.5 mg, 8.3% at 9 mg and 11.1% at 17.2 mg. Results vary; achieved alongside diet and activity.
What Foundayo could mean for you.
Set the slider to where you are today and watch the trial average become actual kilograms — with medication and support, versus the same trial's group who had lifestyle changes alone.
An illustration, not a promise — your prescriber sets real expectations.
98kg
on the trial average, −10.9 kg
Started low, stepped up gently.
Everyone begins at the lowest dose and moves up roughly monthly. This titration is the single biggest reason side effects stay manageable — and your prescriber adjusts the pace to you.
Step 1
0.8 mg
Starting dose — at least 30 days
Step 2
2.5 mg
At least 30 days
Step 3
5.5 mg
At least 30 days
Step 4
9 mg
Step 5
14.5 mg
Maximum
17.2 mg
Held at the dose that suits you
Foundayo
questions.
The questions we hear most about Foundayo. Anything else, write to info@pprx.co.uk.
When will Foundayo be available from PPRX?
What is Foundayo?
Do I have to take it on an empty stomach?
How much weight do people lose on Foundayo?
How is Foundayo different from the Wegovy Pill?
What can I take in the meantime?
From the journal.
Essays from the clinicians who write your prescriptions — explainers, second-look reviews, and the occasional plain-English correction.
Are You Drinking Enough? The Simple Hydration Check
Hydration is one of the easiest healthy habits to neglect. Drink regularly through the day, and take a 7-day challenge to keep water within reach.
Could Your Sleep Routine Be Better? Try a 7-Day Reset
Sleep is easy to sacrifice when life gets busy. Concentrate on the basics for seven days and see whether you notice a difference.
Hayfever & Air Purifiers
Pollen from grasses falls in September, but damp weather brings other triggers. Air purifier or dehumidifier: which one suits your symptoms?
Medically reviewedThis Foundayo page is reviewed by Omar Kadir, Superintendent Pharmacist, MPharm (GPhC 2078291). For full prescribing and safety information, see the patient information leaflet supplied with your medicine or the electronic medicines compendium.
Be first to know when it's here.
One email, the day Foundayo is available to order from PPRX. Nothing else unless you ask for it.
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